Dual-catalytic systems for functionalization of unreactive sites of molecules
NaMeS students are invited to IPC PAS Seminar within Dream Chemistry Lecture Series delivered by:
Prof. Paweł Dydio
Institute of Science and Supramolecular Engineering,
University of Strasbourg & CNRS, Strasbourg, France
Thursday, 6th June, 2019, 10.00
Assembly hall of the IPC PAS
Catalytic functionalization reactions occur readily at sites of starting materials that are both innately reactive and sterically accessible or that are predisposed by a functional group capable to direct a catalyst. However, selective reactions at unbiased sites of substrates remain challenging and typically require additional pre-activation or directing group installation steps, or the use of highly reactive reagents. Therefore, the synthetic methodologies enabling for direct and selective functionalization of typically unreactive sites are highly desired.
Here I will present our studies dedicated to the development of dual-catalytic systems that enable selective functionalization reactions of substrates at their unreactive sites, such as ubiquitous unactivated C-H bonds. Our strategy rests on merging a metal-catalyzed reversible reaction and a metal-catalyzed functionalization reaction. Due to the mild reagents and conditions of both the reversible reaction and the functionalization reaction, the devised methodologies are general and compatible with a broad scope of substrates, including natural product-like molecules. These studies highlight the potential of the multi-catalytic approach to address challenging transformations to circumvent multi-step procedures and use of highly reactive reagents in organic synthesis.