Resonator-Based Spectroscopy: Sizing Cells and Large Molecules
NaMeS students are invited to IPC PAS Seminar within Dream Chemistry Lecture Series delivered by:
Dr. M. Selim Hanay
Dept. of Mechanical Engineering, Bilkent University, Ankara, Turkey,
National Nanotechnology Research Center (UNAM), Bilkent University, Ankara, Turkey
Thursday, 21st March, 2019, 10.00
Assembly hall of the IPC PAS
Mechanical and Electromagnetic Resonators at the micro/nanoscale can be used as exquisite sensors of physical changes, such as the mass and polarizability of a species. We will explore two such sensing paradigms in this talk:
1) Nanoelectromechanical Systems (NEMS) for the Mass Spectrometry of large single biomolecules and nanoparticles, and
2) Microfluidics-Integrated Microwave Sensors for sizing of single cells.
In the first half of the talk (NEMS based Mass Spectrometry), I will argue that conventional forms of Mass Spectrometry face certain challenges when the molecular weight of the species becomes larger than the MegaDalton range which is the regime for large biomolecules, organelles and viruses. In this mass range, nanomechanical devices can offer novel advantages in terms of mass spectrometry, and beyond —such as the simultaneous extraction of molecular shape information. The principles developed for the mechanical resonators can be extended to electromagnetic resonators. For instance, the microwave frequency range seems extremely advantageous for accurate sizing of single-cells in a microfluidic environment. Thus, in the second half of my talk, I will focus on this new approach, a radar for cells, for performing real-time single cell analysis.