Microfluidic device for monodisperse droplets production

The invention describes geometry of the microfluidic device for production of monodisperse micrometer-sized emulsions. Presented device splits a sample into a library of monodisperse droplets of one liquid in another, immiscible liquid. Device
produces aqueous droplets in fluorinated oil containing surfactant, 30-100 nL in volume, coefficient of variation<5%. Other droplets can be produced using microfluidic devices based on proposed invention.


Adam Opalski, Karol Makuch, Yu-Kai Lai, Piotr Garstecki

Advantages / Innovative aspects

Presented invention outperforms solutions found in literature as it offers:

  • higher throughput of droplet production
  • wider flowrate rate range for which the produced droplets are still monodisperse


  • encapsulation of biologically active ingredients
  • monodisperse gel particles production
  • production of nanoparticles
  • culturing microorganisms in droplet
  • in vitro drug screening

State of the progress
stage of research stage of development stage of prototype

Intellectual property rights
Patent application in Poland

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 711859.